Assay
Age
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Immunohistochemistry (section)
10.5 DPC
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Runx1 runt related transcription factor 1 (Synonyms: AML1, Cbfa2, Pebp2a2, runt domain, alpha subunit 2) | |
Results | Reference |
1 | J:338615 Coulombe P, Cole G, Fentiman A, Parker JDK, Yung E, Bilenky M, Degefie L, Lac P, Ling MYM, Tam D, Humphries RK, Karsan A, Meis1 establishes the pre-hemogenic endothelial state prior to Runx1 expression. Nat Commun. 2023 Jul 27;14(1):4537 |
1 | J:322780 Fadlullah MZH, Neo WH, Lie-A-Ling M, Thambyrajah R, Patel R, Mevel R, Aksoy I, Do Khoa N, Savatier P, Fontenille L, Baker SM, Rattray M, Kouskoff V, Lacaud G, Murine AGM single-cell profiling identifies a continuum of hemogenic endothelium differentiation marked by ACE. Blood. 2022 Jan 20;139(3):343-356 |
1* | J:300507 Gao P, Chen C, Howell ED, Li Y, Tober J, Uzun Y, He B, Gao L, Zhu Q, Siekmann AF, Speck NA, Tan K, Transcriptional regulatory network controlling the ontogeny of hematopoietic stem cells. Genes Dev. 2020 Jul 1;34(13-14):950-964 |
1 | J:296224 Hsu J, Huang HT, Lee CT, Choudhuri A, Wilson NK, Abraham BJ, Moignard V, Kucinski I, Yu S, Hyde RK, Tober J, Cai X, Li Y, Guo Y, Yang S, Superdock M, Trompouki E, Calero-Nieto FJ, Ghamari A, Jiang J, Gao P, Gao L, Nguyen V, Robertson AL, Durand EM, Kathrein KL, Aifantis I, Gerber SA, Tong W, Tan K, Cantor AB, Zhou Y, Liu PP, Young RA, Gottgens B, Speck NA, Zon LI, CHD7 and Runx1 interaction provides a braking mechanism for hematopoietic differentiation. Proc Natl Acad Sci U S A. 2020 Sep 22;117(38):23626-23635 |
1 | J:340487 Kazenwadel J, Venugopal P, Oszmiana A, Toubia J, Arriola-Martinez L, Panara V, Piltz SG, Brown C, Ma W, Schreiber AW, Koltowska K, Taoudi S, Thomas PQ, Scott HS, Harvey NL, A Prox1 enhancer represses haematopoiesis in the lymphatic vasculature. Nature. 2023 Feb;614(7947):343-348 |
1 | J:220815 Koh FM, Lizama CO, Wong P, Hawkins JS, Zovein AC, Ramalho-Santos M, Emergence of hematopoietic stem and progenitor cells involves a Chd1-dependent increase in total nascent transcription. Proc Natl Acad Sci U S A. 2015 Apr 7;112(14):E1734-43 |
1* | J:73303 Levanon D, Brenner O, Negreanu V, Bettoun D, Woolf E, Eilam R, Lotem J, Gat U, Otto F, Speck N, Groner Y, Spatial and temporal expression pattern of Runx3 (Aml2) and Runx1 (Aml1) indicates non-redundant functions during mouse embryogenesis. Mech Dev. 2001 Dec;109(2):413-7 |
1 | J:346061 Liu Y, Shi L, Chen Y, Luo S, Chen Y, Chen H, Lan W, Lu X, Cao Z, Ye Z, Li J, Yu B, Dzierzak E, Li Z, Autophagy regulates the maturation of hematopoietic precursors in the embryo. Nat Commun. 2024 Mar 15;15(1):2255 |
1 | J:224446 Lizama CO, Hawkins JS, Schmitt CE, Bos FL, Zape JP, Cautivo KM, Borges Pinto H, Rhyner AM, Yu H, Donohoe ME, Wythe JD, Zovein AC, Repression of arterial genes in hemogenic endothelium is sufficient for haematopoietic fate acquisition. Nat Commun. 2015;6:7739 |
1* | J:240101 Lv J, Wang L, Gao Y, Ding YQ, Liu F, 5-hydroxytryptamine synthesized in the aorta-gonad-mesonephros regulates hematopoietic stem and progenitor cell survival. J Exp Med. 2017 Feb;214(2):529-545 |
1 | J:229604 Machon O, Masek J, Machonova O, Krauss S, Kozmik Z, Meis2 is essential for cranial and cardiac neural crest development. BMC Dev Biol. 2015;15:40 |
1 | J:251966 McGarvey AC, Rybtsov S, Souilhol C, Tamagno S, Rice R, Hills D, Godwin D, Rice D, Tomlinson SR, Medvinsky A, A molecular roadmap of the AGM region reveals BMPER as a novel regulator of HSC maturation. J Exp Med. 2017 Dec 4;214(12):3731-3751 |
1 | J:316437 Mirshekar-Syahkal B, Haak E, Kimber GM, van Leusden K, Harvey K, O'Rourke J, Laborda J, Bauer SR, de Bruijn MF, Ferguson-Smith AC, Dzierzak E, Ottersbach K, Dlk1 is a negative regulator of emerging hematopoietic stem and progenitor cells. Haematologica. 2013 Feb;98(2):163-71 |
1 | J:314041 Moazzen H, Venger K, Kant S, Leube RE, Krusche CA, Desmoglein 2 regulates cardiogenesis by restricting hematopoiesis in the developing murine heart. Sci Rep. 2021 Nov 4;11(1):21687 |
1 | J:342845 Munera JO, Kechele DO, Bouffi C, Qu N, Jing R, Maity P, Enriquez JR, Han L, Campbell I, Mahe MM, McCauley HA, Zhang X, Sundaram N, Hudson JR, Zarsozo-Lacoste A, Pradhan S, Tominaga K, Sanchez JG, Weiss AA, Chatuvedi P, Spence JR, Hachimi M, North T, Daley GQ, Mayhew CN, Hu YC, Takebe T, Helmrath MA, Wells JM, Development of functional resident macrophages in human pluripotent stem cell-derived colonic organoids and human fetal colon. Cell Stem Cell. 2023 Nov 2;30(11):1434-1451.e9 |
1 | J:301549 Munro DAD, Bradford BM, Mariani SA, Hampton DW, Vink CS, Chandran S, Hume DA, Pridans C, Priller J, CNS macrophages differentially rely on an intronic Csf1r enhancer for their development. Development. 2020 Dec 15;147(23):dev194449 |
1 | J:344834 Ning X, Du J, Gong Y, Yao Y, Bai Z, Ni Y, Li Y, Li Z, Zhao H, Zhou J, Liu B, Lan Y, Hou S, Divergent expression of Neurl3 from hemogenic endothelial cells to hematopoietic stem progenitor cells during development. J Genet Genomics. 2023 Sep;50(9):661-675 |
1 | J:326086 Sinha T, Lammerts van Bueren K, Dickel DE, Zlatanova I, Thomas R, Lizama CO, Xu SM, Zovein AC, Ikegami K, Moskowitz IP, Pollard KS, Pennacchio LA, Black BL, Differential Etv2 threshold requirement for endothelial and erythropoietic development. Cell Rep. 2022 May 31;39(9):110881 |
1* | J:312489 Tang W, He J, Huang T, Bai Z, Wang C, Wang H, Yang R, Ni Y, Hou J, Wang J, Zhou J, Yao Y, Gong Y, Hou S, Liu B, Lan Y, Hlf Expression Marks Early Emergence of Hematopoietic Stem Cell Precursors With Adult Repopulating Potential and Fate. Front Cell Dev Biol. 2021;9:728057 |
1 | J:228807 Umansky KB, Gruenbaum-Cohen Y, Tsoory M, Feldmesser E, Goldenberg D, Brenner O, Groner Y, Runx1 Transcription Factor Is Required for Myoblasts Proliferation during Muscle Regeneration. PLoS Genet. 2015 Aug;11(8):e1005457 |
1 | J:326087 Yang Y, Mumau M, Tober J, Zhu Q, Bennett L, Hong C, Sung D, Keller T, Uzun Y, Gao P, Shewale S, Chen M, Yang J, Chen X, Thomas SA, Tan K, Speck NA, Kahn ML, Endothelial MEKK3-KLF2/4 signaling integrates inflammatory and hemodynamic signals during definitive hematopoiesis. Blood. 2022 May 12;139(19):2942-2957 |
1 | J:304773 Yvernogeau L, Klaus A, Maas J, Morin-Poulard I, Weijts B, Schulte-Merker S, Berezikov E, Junker JP, Robin C, Multispecies RNA tomography reveals regulators of hematopoietic stem cell birth in the embryonic aorta. Blood. 2020 Aug 13;136(7):831-844 |
1 | J:269471 Yzaguirre AD, Padmanabhan A, de Groh ED, Engleka KA, Li J, Speck NA, Epstein JA, Loss of neurofibromin Ras-GAP activity enhances the formation of cardiac blood islands in murine embryos. Elife. 2015 Oct 13;4:e07780 |
1* | J:233748 Yzaguirre AD, Speck NA, Extravascular endothelial and hematopoietic islands form through multiple pathways in midgestation mouse embryos. Dev Biol. 2016 Jul 1;415(1):111-21 |
1* | J:310645 Zhang Y, McGrath KE, Ayoub E, Kingsley PD, Yu H, Fegan K, McGlynn KA, Rudzinskas S, Palis J, Perkins AS, Mds1(CreERT2), an inducible Cre allele specific to adult-repopulating hematopoietic stem cells. Cell Rep. 2021 Aug 17;36(7):109562 |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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